Administering self-injections is not an enjoyable experience, but the needles are very thin and small. Most donors find the experience gets easier after each shot. For the actual egg retrieval, you won’t feel anything since you’ll be asleep under conscious sedation. Once you wake up, you’ll probably be a little groggy. You may also experience some cramping and bloating, similar to what you may feel during a menstrual cycle. Tylenol is typically sufficient to quell any discomfort. Most donors are able to resume normal activity and return to work/school the next day. Pain tolerance varies widely from person to person. For for more information, check out our blog How Painful is Egg Donation?